Posts Tagged ‘apigenin’

Plant compound found to stop cancer cells in their tracks

May 18, 2011

A University of Missouri researcher has made a discovery about a compound hidden in some fruits and vegetables that can essentially stop certain kinds of breast-cancer cells in their tracks.

Professor Salman Hyder exposed rats with synthetic-hormone-induced breast cancers to a plant compound called apigenin.

The rats that received the apigenin extract developed fewer tumours and had significant delays in the development of tumours, as compared with rats that did not receive the extract.

In order for cancer tumours to grow and spread they need to continually recruit new blood vessels to supply them with a flow of nutrients. In the type of tumour in this study, the cancer cells encourage the growth of new blood vessels within the tumours, which then serve as nutrient pathways feeding and growing the cancer.

What Professor Hyder discovered was that the apigenin blocked the new blood vessels from forming, effectively cutting off the tumours’ food supply. Without the continuous flow of nutrients, the growth of the tumours was stunted…and in some cases even stopped altogether.

In an earlier, unrelated study performed by researchers from Brigham and Women’s Hospital and Harvard Medical School, it was found that women who consumed the most apigenin-rich foods had a 28% reduced risk of developing ovarian cancer as compared with women who ate the least of them.

Foods rich in the flavonoid, apigenin, include celery, parsley, apples, tomato sauce, endive, beans, cherries, leeks, onions, tomatoes, grapes, and red wine.

Source:  Apigenin prevents development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumors in Sprague-Dawley rats, Cancer Prevention Research, Published Online First April 19, 2011; doi: 10.1158/1940-6207.CAPR-10-0382